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Article Dans Une Revue Chemical Communications Année : 2015

pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes

Résumé

Two bolaamphiphilic quadrupoles built from a fluorene core conjugated with azine endgroups were designed and successfully used to stain GUV membranes. Their quadrupolar character induces both a shift of the pKa values close to the physiological pH and large two-photon absorption responses (i.e. over 1000 GM for acidic forms). As such they hold promise as ratiometric two-photon pH probes for monitoring slight variations of pH near cell membranes using two-photon excitation in the NIR region

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Chimie
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Dates et versions

hal-01231149 , version 1 (02-12-2015)

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Jonathan Daniel, Cristiano Mastrodonato, Aude Sourdon, Guillaume Clermont, Jean-Marie Vabre, et al.. pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes. Chemical Communications, 2015, 51 (83), pp.15245--15248. ⟨10.1039/C5CC04573H⟩. ⟨hal-01231149⟩
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