%0 Journal Article %T Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light %+ Department of Chemistry, Graduate School of Science, Hiroshima University (HIRODAI) %+ JST-CREST %+ National Institute of Advanced Industrial Science and Technology (AIST) %+ Niigata University %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Laboratory of Structural Physiology, Graduate School of Medicine (CDBIM) %+ Laboratory of Structural Physiology (CDBIM) %+ Advanced Ultrafast Laser Research Center %A Komori, Naomitsu %A Jakkampudi, Satish %A Motoishi, Ryusei %A Abe, Manabu %A Kamada, Kenji %A Furukawa, Ko %A Katan, Claudine %A Sawada, Wakako %A Takahashi, Noriko %A Kasai, Haruo %A Xue, Bing %A Kobayashi, Takayoshi %Z C. K. acknowledges the HPC resources of CINES and of IDRIS under the allocations 2014-[x2014080649] made by GENCI (Grand Equipement National de Calcul Intensif). %< avec comité de lecture %@ 1359-7345 %J Chemical Communications %I Royal Society of Chemistry %V 52 %N 2 %P 331-334 %8 2016 %D 2016 %R 10.1039/C5CC07664A %M 26515230 %K Two-photon absorption 2PA %K TD-DFT %K Glutamate release %K Photoactivation %Z Chemical Sciences/Theoretical and/or physical chemistry %Z Chemical Sciences/Organic chemistry %Z Cognitive science/NeuroscienceJournal articles %X A new chromophore, 2-(4-nitrophenyl)benzofuran (NPBF), was designed for two-photon (TP) uncaging using near-IR light. The TP absorption (TPA) cross-sections of the newly designed NPBF chromophore were determined to be 18 GM at 720 nm and 54 GM at 740 nm in DMSO. The TP uncaging reaction of a caged benzoate with the NPBF chromophore quantitatively produced benzoic acid with an efficiency (δu) of ∼5.0 GM at 740 nm. The TP fragmentation of an EGTA unit was observed with δu = 16 GM. This behavior makes the new chromophore a promising TP photoremovable protecting group for physiological studies. %G English %2 https://univ-rennes.hal.science/hal-01228569/document %2 https://univ-rennes.hal.science/hal-01228569/file/chemcom2015-glutamateUncaging-withpagenumbers.pdf %L hal-01228569 %U https://univ-rennes.hal.science/hal-01228569 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ ISCR %~ ISCR-CTI %~ UR1-SPM %~ GENCI %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ UR1-MMS %~ TEST2-HALCNRS %~ TEST3-HALCNRS