%0 Journal Article %T In vitro chemical and biological effects of Ag, Cu and Cu + Zn adjunction in 46S6 bioactive glasses %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Foie, métabolismes et cancer %A Bunetel, L. %A Wers, E. %A Novella, A. %A Bodin, A %A Pellen-Mussi, P. %A Oudadesse, H %< avec comité de lecture %J Materials Research Express %I IOP Publishing Ltd %V 2 %N 9 %P 095402 %8 2015 %D 2015 %R 10.1088/2053-1591/2/9/095402 %Z Life Sciences [q-bio]Journal articles %X Three bioactive glasses belonging to the system SiO2-CaO- Na2O-P2O5 elaborated by conventional melt-quenching techniques were doped with silver, copper and copper + zinc. They were characterized using the usual physical methods. Human osteoblast cells Saos-2 and human endothelial cells EAhy926 were used for viability assays and to assess the metallic ions, self toxicity. Human monocyte cells THP-1 were used to measure interleukins IL1β and IL6 release. Glass chemical structures did not vary much on introduction of metal ions. A layer of hydroxyapatite was observed on every glass after 30 days of SBF immersion. A proliferative action was seen on Saos-2 after 24 h of incubation, EAhy926 growth was not affected. For both cell lines, a moderate cytotoxicity was found after 72 h. Dose-dependent toxic effects of Ag, Cu and Zn ions were observed on Saos-2 and EAhy926 cells. Measured CD50 of silver against these two cell lines were 8 to 20 fold lower than copper and zinc’s. Except undoped control glass, all doped glasses tested showed anti-inflammatory properties by preventing IL1β and IL6 excretion by differentiated THP-1. In conclusion, strictly monitored adjunction of metal ions to bioglasses ensures good anti-inflammatory properties without altering their biocompatibility %G English %L hal-01195744 %U https://univ-rennes.hal.science/hal-01195744 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ IFR140 %~ ISCR %~ SCR_VC %~ U991 %~ STATS-UR1 %~ NUMECAN %~ UR1-SPM %~ INC-CNRS %~ NUMECAN-EXPRES %~ UR1-UFR-SVE %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ UR1-SDLMJONCH %~ UR1-SDV %~ IVER %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ UR1-MMS %~ UR1-BIO-SA %~ TEST2-HALCNRS %~ TEST3-HALCNRS