%0 Journal Article %T Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study %+ Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau] %+ Service d'hématologie pédiatrique %+ Centre Hospitalier Universitaire [Rennes] %+ Institut de Génétique et Développement de Rennes (IGDR) %A Orsi, L. %A Rudant, J. %A Ajrouche, R. %A Leverger, G. %A Baruchel, A. %A Nelken, B. %A Pasquet, M. %A Michel, G. %A Bertrand, Yves %A Ducassou, S. %A Gandemer, V. %A Lutz, P. %A Saumet, L. %A Moreau, P. %A Hemon, D. %A Clavel, J %< avec comité de lecture %@ 0957-5243 %J Cancer Causes and Control %I Springer Verlag %V 26 %N 7 %P 1003--1017 %8 2015 %D 2015 %R 10.1007/s10552-015-0593-5 %M 25956268 %K Alcohol %K Biomedicine general %K Cancer Research %K Childhood acute leukemia %K Coffee %K Epidemiology %K Hematology %K Oncology %K Parental smoking %K Public Health %Z Life Sciences [q-bio]Journal articles %X Purpose To investigate the role of parental smoking during pre-conception and pregnancy, maternal beverage consumption (alcohol, coffee and tea) during pregnancy and their possible interactions, in the etiology of childhood acute leukemia (CL). Methods The ESTELLE study included 747 cases of CL [636 cases of acute lymphoblastic leukemia (ALL) and 100 cases of acute myeloblastic leukemia (AML)] diagnosed in France in 2010–2011 and 1,421 population controls frequency-matched with the cases on age and gender. Data were obtained from structured telephone questionnaires administered to the mothers. The odds ratios (OR) and their 95 % confidence intervals were estimated using unconditional logistic regression models adjusted for potential confounders. Results AML, but not ALL, was non-significantly associated with alcohol drinking during pregnancy [OR = 1.3 (0.8–2.0)] with a significant positive dose–response trend (p-trend = 0.02). Pre-conception paternal smoking was significantly associated with ALL [OR = 1.2 (1.1–1.5)] and AML [OR = 1.5 (1.0–2.3)]. CL was not associated with maternal smoking [OR = 1.0 (0.8–1.2)], or maternal coffee [OR = 0.9 (0.8–1.1)] or tea drinking [OR = 0.9 (0.8–1.1)] during pregnancy. However, a high consumption of coffee (\textgreater2 cups/day) was significantly associated with ALL [OR = 1.3 (1.0–1.8)]. Conclusions The findings constitute additional evidence that maternal alcohol drinking during pregnancy may be involved in AML, and that paternal smoking before pregnancy may be a risk factor for CL. The role of maternal coffee drinking in CL remains unclear and should be investigated further in consortium analyses and in large birth cohort studies with exposure assessment more contemporaneous with the exposure, before the occurrence of the disease %G English %L hal-01175534 %U https://univ-rennes.hal.science/hal-01175534 %~ UNIV-PARIS7 %~ UPMC %~ UNIV-RENNES1 %~ CNRS %~ APHP %~ IFR140 %~ RNTSE %~ STATS-UR1 %~ IGDR-EGO %~ UR1-HAL %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ ALLIANCE-SU