%0 Journal Article %T Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study %+ Laboratoire Traitement du Signal et de l'Image (LTSI) %+ CIC-IT Rennes %+ Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] %+ Service de Pharmacologie [Rennes] %+ Service de cardiologie %+ Service de cardiologie [CHU Rouen] %+ Service de cardiologie [Montpellier] %+ CHU Saint-Antoine [AP-HP] %+ Department of Cardiology, Karolinska University Hospital %A Donal, Erwan %A Lund, Lars H. %A Oger, Emmanuel %A Hage, Camilla %A Persson, Hans %A Reynaud, Amelie %A Ennezat, Pierre-Vladimir %A Bauer, Fabrice %A Sportouch-Dukhan, Catherine %A Drouet, Elodie %A Daubert, Jean-Claude %A Linde, Cecilia %A Investigators, Karen %< avec comité de lecture %@ 1875-2136 %J Archives of cardiovascular diseases %I Elsevier/French Society of Cardiology %V 107 %N 2 %P 112--121 %8 2014 %D 2014 %R 10.1016/j.acvd.2013.11.002 %M 24388161 %K Prospective Studies %K Prognosis %K Brain %K Peptide Fragments %K Predictive Value of Tests %K Prevalence %K Electrocardiography %K Comorbidity %K Echocardiography %K Age Factors %K Aged %K 80 and over %K Biological Markers %K Time Factors %K Stroke Volume %K Sweden %K Ventricular Function %K Left %K Humans %K Hypertension %K Male %K Natriuretic Peptide %K Heart Failure %K France %K Female %K Sex Factors %K Risk Factors %K Registries %Z Life Sciences [q-bio]Journal articles %X BACKGROUND: Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failure patients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity. AIMS: To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up. METHODS: Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)\textgreater100 ng/L or N-terminal pro-BNP (NT-proBNP)\textgreater300 ng/L and left ventricular ejection fraction (LVEF)\textgreater45%. RESULTS: The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P\textless0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2). CONCLUSIONS: Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709). %G English %L hal-01147020 %U https://univ-rennes.hal.science/hal-01147020 %~ UNIV-RENNES1 %~ LTSI %~ APHP %~ HL %~ CIC %~ STATS-UR1 %~ COMUE-NORMANDIE %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-MATH-STIC %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UNIROUEN %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ SU-TI %~ UR1-MATH-NUM %~ UR1-BIO-SA %~ ALLIANCE-SU %~ TEST3-HALCNRS