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Article Dans Une Revue American Journal of Hematology Année : 2015

Monoclonal anti-transferrin antibody: A paradigm for better understanding of iron metabolism.

Résumé

A 82 years old patient was admitted for persisting abnormalities of iron metabolism parameters in the context IgG kappa monoclonal gammopathy, discovered 12 years before, and classified as MGUS (monoclonal gammopathy of undetermined significance). Serum iron and transferrin concentration were constantly extremely high (96.9 μmol/L and 5.0 g/L, respectively), transferrin saturation was elevated (77.5% ; N<45%) and serum ferritin moderately increased (608μg/L ; N<300 μg/L). Hemochromatosis was ruled out(1) : no tissue iron overload was present and genetic studies searching for mutations in HFE and non HFE genes, were negative (p.Cys282Tyr mutation, HJV (HFE2), HAMP, TFR2, BMP6, SLC40A1 and FTL).
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Dates et versions

hal-01134382 , version 1 (29-10-2015)

Identifiants

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Martine Ropert, Lénaïck Détivaud, Béatrice Fimbel d'Hauthuille, Mathilde Gautier, Patricia Leroyer, et al.. Monoclonal anti-transferrin antibody: A paradigm for better understanding of iron metabolism.. American Journal of Hematology, 2015, 90 (6), pp.E129-E130. ⟨10.1002/ajh.24004⟩. ⟨hal-01134382⟩
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