Monoclonal anti-transferrin antibody: A paradigm for better understanding of iron metabolism.
Résumé
A 82 years old patient was admitted for persisting abnormalities of iron metabolism
parameters in the context IgG kappa monoclonal gammopathy, discovered 12 years before,
and classified as MGUS (monoclonal gammopathy of undetermined significance). Serum iron
and transferrin concentration were constantly extremely high (96.9 μmol/L and 5.0 g/L,
respectively), transferrin saturation was elevated (77.5% ; N<45%) and serum ferritin
moderately increased (608μg/L ; N<300 μg/L). Hemochromatosis was ruled out(1) : no tissue
iron overload was present and genetic studies searching for mutations in HFE and non HFE
genes, were negative (p.Cys282Tyr mutation, HJV (HFE2), HAMP, TFR2, BMP6, SLC40A1 and
FTL).
Origine : Fichiers produits par l'(les) auteur(s)
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