Pericytes, Microvasular Dysfunction, and Chronic Rejection. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Transplantation Année : 2015

Pericytes, Microvasular Dysfunction, and Chronic Rejection.

Résumé

Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention.

Dates et versions

hal-01134347 , version 1 (23-03-2015)

Identifiants

Citer

Malgorzata Kloc, Jacek Z Kubiak, Xian C Li, Rafik M Ghobrial. Pericytes, Microvasular Dysfunction, and Chronic Rejection.. Transplantation, 2015, 99 (4), pp.658-667. ⟨10.1097/TP.0000000000000648⟩. ⟨hal-01134347⟩
37 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More