%0 Journal Article %T Design, synthesis and biological evaluation of new inhibitors of Bax/Bcl-xL interaction in cancer cells. %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Centre de Recherche en Cancérologie Nantes-Angers (CRCNA) %+ Laboratoire Bioprojet %A Vo, Duc Duy %A Gautier, Fabien %A Barillé-Nion, Sophie %A Juin, Philippe %A Levoin, Nicolas %A Grée, René %< avec comité de lecture %@ 0960-894X %J Bioorganic and Medicinal Chemistry Letters %I Elsevier %V 24 %N 7 %P 1758-61 %8 2014-04-01 %D 2014 %R 10.1016/j.bmcl.2014.02.035 %M 24602902 %Z Chemical Sciences %Z Life Sciences [q-bio]Journal articles %X We describe the synthesis of a series of new molecules containing phenol and triazoles moieties, compounds which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in cancer cells, by using BRET assays, and to induce cell death. Several derivatives exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol A and ABT-737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity. %G English %L hal-01116303 %U https://univ-rennes.hal.science/hal-01116303 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ ISCR %~ UNAM %~ SCR-PNSCM %~ STATS-UR1 %~ UR1-SPM %~ INC-CNRS %~ CRCNA %~ UR1-UFR-SPM %~ UR1-HAL %~ ISCR-CORINT %~ UR1-SDLM %~ UR1-SDLMJONCH %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ ISCR-CORINT1 %~ UR1-MMS %~ ISCR-CORINT3 %~ TEST2-HALCNRS