One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2014

One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives

Résumé

The regioselective 2- or 5-arylation of imidazole derivatives with aryl halides using palladium catalysts has been described in recent years; whereas the arylation at both C2 and C5 carbons of imidazoles in high yields has not been performed. We found conditions allowing the access to these 2,5-diarylimidazoles via a one pot reaction. The choice of the base was found to be crucial to obtain these products in high yields. Using CsOAc as the base, DMA as the solvent and only 2 mol % of the phosphine-free Pd(OAc)2 the catalyst, the target 2,5-diarylated imidazoles were obtained in moderate to good yields with a wide variety of aryl bromides. Substituents such as fluoro, trifluoromethyl, formyl, acetyl, propionyl, ester, nitro or nitrile on the aryl bromide were tolerated. Sterically congested aryl bromides or heteroaryl bromides can also be employed. Surprisingly the nature of the substituent at position 1 on the imidazole derivative exhibits a huge influence on the reaction.

Domaines

Chimie
Fichier principal
Vignette du fichier
One Pot Pd(OAc)2-Catalysed 2,5-Diarylation of Imidazoles Derivatives.pdf (357.48 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01114981 , version 1 (02-07-2015)

Identifiants

Citer

Abdelilah Takfaoui, Liqin Zhao, Rachid Touzani, Jean-François Soulé, Pierre H. Dixneuf, et al.. One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives. Tetrahedron, 2014, 70 (44), pp.8316-8323. ⟨10.1016/j.tet.2014.09.012⟩. ⟨hal-01114981⟩
136 Consultations
220 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More