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Article Dans Une Revue Small Press Année : 2014

Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves.

Olivier Mongin
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Résumé

Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.

Domaines

Chimie organique

Dates et versions

hal-01093766 , version 1 (11-12-2014)

Identifiants

Citer

Jonas Croissant, Arnaud Chaix, Olivier Mongin, Miao Wang, Sébastien Clément, et al.. Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves.. Small Press, 2014, 10 (9), pp.1752-1755. ⟨10.1002/smll.201400042⟩. ⟨hal-01093766⟩
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