%0 Journal Article %T Ruptures d'approvisionnement en médicaments anti-infectieux: causes et conséquences [Shortages in anti-infective medicines: causes and consequences] %T Ruptures d'approvisionnement en médicaments anti-infectieux: causes et conséquences %+ Service de pharmacie %+ COMEDIMS %+ Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes] %+ Centre d'Investigation Clinique [Rennes] (CIC) %+ Fonction, structure et inactivation d'ARN bactériens %A Luans, Caroline %A Cardiet, Isabelle %A Rogé, Pauline %A Baslé, Béatrice %A Le Corre, Pascal %A Revest, Matthieu %A Michelet, Christian %A Tattevin, Pierre %< avec comité de lecture %@ 0399-077X %J Médecine et Maladies Infectieuses %I Elsevier Masson %V 44 %N 10 %P 470–477 %8 2014-10 %D 2014 %R 10.1016/j.medmal.2014.07.014 %M 25282606 %K antibacterial %K vaccine %K drug shortages %K anti-infective %K anti-infectieux %K antibiotiques %K vaccins %K Rupture d’approvisionnement %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X Anti-infective drugs stock-outs are increasingly frequent, and this is unlikely to change. There are numerous causes for this, mostly related to parameters difficult to control: i) 60 to 80% of raw material or components are produced outside of Europe (compared to 20% 30 years ago), with subsequent loss of independence for their procurement; ii) the economic crisis drives the pharmaceutical companies to stop producing drugs of limited profitability (even among important drugs); iii) the enforcement of regulatory requirements and quality control procedures result in an increasing number of drugs being blocked during production. The therapeutic class most affected by drug stock-outs is that of anti-infective drugs, especially injectable ones, and many therapeutic dead ends have recently occurred. We provide an update on this issue, and suggest 2 major actions for improvement: i) to implement a group dedicated to anticipating drug stock-outs within the anti-infective committee in each health care center, with the objectives of organizing and coordinating the response whenever a drug stock-out is deemed at risk (i.e., contingency plans, substitution, communication to prescribers); ii) a national reflection lead by scientific societies, in collaboration with government agencies, upstream of the most problematic drug stock-outs, to elaborate and disseminate consensus guidelines for the management of these stock-outs. %G English %2 https://univ-rennes.hal.science/hal-01077286/document %2 https://univ-rennes.hal.science/hal-01077286/file/Ruptures%20d%E2%80%99approvisionnement%20en%20m%C3%A9dicaments%20anti-infectieux_accepted.pdf %L hal-01077286 %U https://univ-rennes.hal.science/hal-01077286 %~ UNIV-RENNES1 %~ IFR140 %~ HL %~ U835 %~ CIC %~ CIC203 %~ STATS-UR1 %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ IRSET-2-EX-HIAEC %~ IRSET-9-EX-ERD %~ UR1-BIO-SA