Influence of 1,3-difluorobenzene substituents for palladium-catalyzed direct arylations. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2013

Influence of 1,3-difluorobenzene substituents for palladium-catalyzed direct arylations.

Résumé

The influence of electron-withdrawing and electron-donating substituents (nitro, nitrile, chloro, bromo, methoxy or amino) on 1,3-difluorobenzenes in their palladium-catalyzed direct C2 arylation has been explored. With most substituents, the reaction proceeds nicely using air-stable palladium catalysts (0.5-2 mol-%) and KOAc/DMA. In general, very regioselective C2-arylation was obsd. Moreover, a variety of substituents on the aryl bromide coupling partner (ester, acetyl, formyl, nitro, nitrile, trifluoromethyl, chloro, fluoro or methyl) was tolerated. [on SciFinder(R)]

Dates et versions

hal-01069853 , version 1 (30-09-2014)

Identifiants

Citer

Tao Yan, Charles Beromeo Bheeter, Henri. Doucet. Influence of 1,3-difluorobenzene substituents for palladium-catalyzed direct arylations.. European Journal of Organic Chemistry, 2013, 2013, pp.7152--7163. ⟨10.1002/ejoc.201301131⟩. ⟨hal-01069853⟩
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