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Article Dans Une Revue Interceram Année : 2013

Bioactivity and drug delivering ability of a chitosan/46S6 melted bioactive glass biocomposite scaffold.

M. Mabrouk
  • Fonction : Auteur
A. A. Mostafa
  • Fonction : Auteur
H. Oudadesse
A. A. Mahmoud
  • Fonction : Auteur
M. I. El-Gohary
  • Fonction : Auteur

Résumé

Macroporous chitosan scaffolds (Ch) reinforced by quaternary bioactive glass with the 46S6 system of 46 mass-% SiO2, 24 mass-% CaO, 24 mass-% Na2O, 6 mass-% P2O5 prepd. by a melting technique (MB) loaded with ciprofloxacin (Cip) were prepd. by a lyophilization technique. Theses porous composite materials were esp. designed as both a drug carrier for controlled drug release and a scaffold for bone regeneration. The biodegrdn. rate and in-vitro mineralization of the prepd. scaffolds were performed by soaking the scaffolds in simulated body fluid (SBF). Phase identification, microstructure, porosity, bioactivity, mech. properties and drug release ability in phosphate buffer soln. (PBS) were characterized by XRD, FTIR, mercury porosimeter, SEM coupled with EDS, ICP-OES, a universal testing machine and a UV-spectrophotometer. The addn. of bioactive glass resulted in the formation of an appetite layer on the scaffolds surfaces. The fracture toughness (Klc) of Ch is enhanced by incorporation of glass, as the glass content increases the Klc increase. Incorporation of Cip up to 20 mass-% into Ch/MB scaffolds was successfully achieved during the prepn. procedure. The morphol., structure and release behavior of the loaded scaffolds were found to be highly dependable on the glass content and drug concns. [on SciFinder(R)]

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hal-01069714 , version 1 (29-09-2014)

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  • HAL Id : hal-01069714 , version 1

Citer

M. Mabrouk, A. A. Mostafa, H. Oudadesse, A. A. Mahmoud, M. I. El-Gohary. Bioactivity and drug delivering ability of a chitosan/46S6 melted bioactive glass biocomposite scaffold.. Interceram, 2013, 62 (6), pp.444--452. ⟨hal-01069714⟩
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