Structure of a New Bioactive Agent Containing Combined Antibacterial and Antifungal Pharmacophore Sites: 4-\[(E)-(5-Bromo-2-hydroxyphenyl)methylidene]amino\-N-(5-methyl-1,2- oxazol-3-yl)benzenesulfonamide - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Chemical Crystallography Année : 2011

Structure of a New Bioactive Agent Containing Combined Antibacterial and Antifungal Pharmacophore Sites: 4-\[(E)-(5-Bromo-2-hydroxyphenyl)methylidene]amino\-N-(5-methyl-1,2- oxazol-3-yl)benzenesulfonamide

Zahid H. Chohan
  • Fonction : Auteur
Hazoor A. Shad
  • Fonction : Auteur
Loic Toupet
Mehmet Akkurt
  • Fonction : Auteur

Résumé

The title compound (3), C17H14BrN3O4S, is a Schiff base compound of 5-bromosalicylaldehyde (1) and sulfamethoxazole (2). The structure of (3) was determined by spectral (IR, H-1 and C-13 NMR), elemental analyses and X-ray diffraction data. Compound (3) crystallizes in the monoclinic space group C2/c, with a = 31.936(3), b = 6.2571(5), c = 16.903(1) angstrom, beta = 94.867(8), V = 3365.5(5) angstrom(3), Z = 8. In the molecule of compound (3), the molecule is bent at the S atom with a C-SO2-NH-C torsion angle of -86.3(3)degrees. Pairs of molecules, related by inversion centres, form intermolecular N-H center dot center dot center dot N hydrogen bonds to produce a dimer. An intramolecular phenolic O-H center dot center dot center dot N hydrogen bond is also formed. Intermolecular hydrogen bonding and pi-pi stacking hold the molecules together. The average distance between stacked benzene ring planes is 3.625(2) angstrom.

Dates et versions

hal-01068817 , version 1 (26-09-2014)

Identifiants

Citer

Zahid H. Chohan, Hazoor A. Shad, Loic Toupet, Taibi Ben Hadda, Mehmet Akkurt. Structure of a New Bioactive Agent Containing Combined Antibacterial and Antifungal Pharmacophore Sites: 4-\[(E)-(5-Bromo-2-hydroxyphenyl)methylidene]amino\-N-(5-methyl-1,2- oxazol-3-yl)benzenesulfonamide. Journal of Chemical Crystallography, 2011, 41 (2), pp.159-162. ⟨10.1007/s10870-010-9856-x⟩. ⟨hal-01068817⟩
103 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More