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Article Dans Une Revue Journal of Thoracic Oncology Année : 2014

Lung cancer in combined pulmonary fibrosis and emphysema: a series of 47 Western patients

Résumé

INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.

Dates et versions

hal-01063912 , version 1 (15-09-2014)

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Nicolas Girard, Sylvain Marchand-Adam, Jean-Marc Naccache, Raphael Borie, Thierry Urban, et al.. Lung cancer in combined pulmonary fibrosis and emphysema: a series of 47 Western patients. Journal of Thoracic Oncology, 2014, 9 (8), pp.1162--1170. ⟨10.1097/JTO.0000000000000209⟩. ⟨hal-01063912⟩
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