%0 Journal Article %T Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. %+ Centre d'Investigation Clinique [CHU Clermont-Ferrand] (CIC 1405) %+ Service d'Oncologie [Vichy] %+ Service de Neurologie [Vichy] %+ Microenvironnement et cancer (MiCa) %+ Service d'hématologie clinique %A Lemal, Richard %A Chaleteix, Carine %A Minard, Patrice %A Roche, Corinne %A Bay, Jacques-Olivier %A Tournilhac, Olivier %A Lamy, Thierry %< avec comité de lecture %@ 2213-0489 %J Leukemia Research Reports %I Elsevier %V 2 %N 1 %P 32-33 %8 2013 %D 2013 %R 10.1016/j.lrr.2013.02.004 %M 24371773 %K Large granular lymphocytic leukemia %K LGL leukemia %K Lambert-Eaton Myasthenic Syndrome %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Human health and pathology/HematologyJournal articles %X Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS. %G English %2 https://univ-rennes.hal.science/hal-00974560/document %2 https://univ-rennes.hal.science/hal-00974560/file/Lemal%20-%20Large%20granular%20lymphocytic%20leukemia.pdf %L hal-00974560 %U https://univ-rennes.hal.science/hal-00974560 %~ INSERM %~ UNIV-RENNES1 %~ IFR140 %~ HL %~ U917 %~ STATS-UR1 %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ MICMAC %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ CHU-CLERMONTFERRAND %~ UR1-BIO-SA