IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Liver International Année : 2012

IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology.

Résumé

'Alarmins' are a group of proteins or molecules that are released from cells during cellular demise to alert the host immune system. Two of them, Interleukin-33 (IL-33) and high-mobility group box-1 (HMGB1), share many similarities of cellular localization, functions and involvement in various inflammatory pathologies including hepatitis. The expressions of IL-33 and HMGB1, and their receptors ST2 and receptor for advanced glycation end products (RAGE), are substantially up-regulated during acute and chronic hepatitis. Recent data evidence a possible protective role of IL-33/ST2 axis during liver injury. A contrast in expression of IL-33 and HMGB1 alarmins were associated with type of hepatocellular death mediated by immune cells or hepato-toxic agents. The massive release of active form of IL-33 from hepatocytes may affect the recruitment and activation of its ST2-positive target immune cells in the liver to confer its alarmin functions. This review highlights the emerging roles of alarmin proteins in various liver pathologies, by focusing on classical HMGB1 and a newly discovered alarmin, the IL-33.

Dates et versions

hal-00874209 , version 1 (17-10-2013)

Identifiants

Citer

Muhammad I Arshad, Claire Piquet-Pellorce, Michel Samson. IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology.. Liver International, 2012, 32 (8), pp.1200-10. ⟨10.1111/j.1478-3231.2012.02802.x⟩. ⟨hal-00874209⟩
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