Ruthenium(II) Catalysed Synthesis of Unsaturated Oxazolines via Arene C-H Bond Alkenylation
Résumé
Monoalkenylation of arene C-H bonds directed by an oxazoline group to afford bifunctional alkenes is described using [RuCl2(p-cymene)]2 as the catalyst in the presence of 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate (BNPAH) and of Cu(OAc)2*H2O under air. This reaction takes place under mild conditions in ethanol at 80 °C and tolerates the oxazoline function.