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Article Dans Une Revue European Journal of Organic Chemistry Année : 2013

Convergent Strategy Towards the Synthesis of Restricted Analogues of Peloruside A

Résumé

A rapid convergent strategy to access unsaturated analogues of peloruside A has been demonstrated. This is depicted as an original C11-C12 aldol connection between a C12-C20 ketone fragment and a C2-C11 pyran fragment bearing an aldehyde function, with high yield and a good level of diastereoselectivity. The desired unsaturated macrocycle was obtained by a late-stage ring closing metathesis reaction.

Domaines

Chimie organique

Dates et versions

hal-00872088 , version 1 (11-10-2013)

Identifiants

Citer

Nicolas Zimmermann, Pierre Pinard, Bertrand Carboni, Pascal Gosselin, Catherine Gaulon-Nourry, et al.. Convergent Strategy Towards the Synthesis of Restricted Analogues of Peloruside A. European Journal of Organic Chemistry, 2013, 2013 (12), pp.2303-2315. ⟨10.1002/ejoc.201201728⟩. ⟨hal-00872088⟩
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