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Article Dans Une Revue Journal of Molecular Catalysis A: Chemical Année : 2013

Asymmetric oxidation of sulfides by hydrogen peroxide catalyzed by chiral manganese porphyrins in water/methanol solution

Hassan Srour
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Joanna Jalkh
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Paul Le Maux
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Soizic Chevance
Marwan Kobeissi
  • Fonction : Auteur

Résumé

An efficient asymmetric oxidation of sulfides catalyzed by water-soluble chiral manganese porphyrin was carried out in presence of cheap and environmentally benign oxidant H2O2 at 25 °C. Prochiral sulfides were converted to respective sulfoxides with up to 100% conversion and up to 57% enantiomeric excess. The present study demonstrated the necessity of water as solvent and imidazole as co-catalyst. Application to the preparation of the optically drug, sulindac, was demonstrated.

Dates et versions

hal-00870853 , version 1 (08-10-2013)

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Hassan Srour, Joanna Jalkh, Paul Le Maux, Soizic Chevance, Marwan Kobeissi, et al.. Asymmetric oxidation of sulfides by hydrogen peroxide catalyzed by chiral manganese porphyrins in water/methanol solution. Journal of Molecular Catalysis A: Chemical, 2013, 370, pp.75-79. ⟨10.1016/j.molcata.2012.12.016⟩. ⟨hal-00870853⟩
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