The anti-apoptotic Bcl-x(L) protein, a new piece in the puzzle of cytochrome c interactome. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2011

The anti-apoptotic Bcl-x(L) protein, a new piece in the puzzle of cytochrome c interactome.

Résumé

A structural model of the adduct between human cytochrome c and the human anti-apoptotic protein Bcl-x(L), which defines the protein-protein interaction surface, was obtained from solution NMR chemical shift perturbation data. The atomic level information reveals key intermolecular contacts identifying new potentially druggable areas on cytochrome c and Bcl-x(L). Involvement of residues on cytochrome c other than those in its complexes with electron transfer partners is apparent. Key differences in the contact area also exist between the Bcl-x(L) adduct with the Bak peptide and that with cytochrome c. The present model provides insights to the mechanism by which cytochrome c translocated to cytosol can be intercepted, so that the apoptosome is not assembled.

Domaines

Matériaux
Fichier principal
Vignette du fichier
journal.pone.0018329.pdf (276.35 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-00869886 , version 1 (04-10-2013)

Identifiants

Citer

Ivano Bertini, Soizic Chevance, Rebecca del Conte, Daniela Lalli, Paola Turano. The anti-apoptotic Bcl-x(L) protein, a new piece in the puzzle of cytochrome c interactome.. PLoS ONE, 2011, 6 (4), pp.e18329. ⟨10.1371/journal.pone.0018329⟩. ⟨hal-00869886⟩
101 Consultations
244 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More