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Article Dans Une Revue Palladium-catalysed direct regioselective C5-arylation of a thiophene bearing a cyclopropyl ketone group at C2 Année : 2013

Palladium-catalysed direct regioselective C5-arylation of a thiophene bearing a cyclopropyl ketone group at C2

Résumé

A thiophene bearing a cyclopropyl ketone group at C2 was successfully employed in palladium-catalysed direct arylation. The reaction proceeds regioselectively at C5 without decomposition of the cyclopropyl ketone substituent. These couplings were performed employing as little as 0.5 mol% of ligand-free Pd(OAc)2 catalyst with electron-deficient aryl bromides. A wide variety of functional groups on the aryl bromide such as nitrile, nitro, acetyl, formyl, benzoyl, ester, trifluoromethyl, fluoro or methoxy was tolerated. © 2013 Elsevier Science. All rights reserved.

Domaines

Catalyse
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Dates et versions

hal-00865557 , version 1 (24-09-2013)

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Anissa Beladhria, Aditya L. Gottumukkala, Chiraz Youssef, Charles Beromeo Bheeter, Hamed Ben Ammar, et al.. Palladium-catalysed direct regioselective C5-arylation of a thiophene bearing a cyclopropyl ketone group at C2. Palladium-catalysed direct regioselective C5-arylation of a thiophene bearing a cyclopropyl ketone group at C2, 2013, 41, pp.119-122. ⟨10.1016/j.catcom.2013.07.014⟩. ⟨hal-00865557⟩
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