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Article Dans Une Revue Tetrahedron Letters Année : 2010

Effect of fluorine or oxygen atom(s) in propargylic position on the reactivity in click chemistry

Résumé

The use of especially designed ω-diynes allows to establish, through competitive reactions, the effect of C-F, C-OH, CF2, Cdouble bond; length as m-dashO and C(OMe)2 substituents on the reactivity of neighbouring triple bonds in click chemistry and this gives not only a reactivity scale but also a direct access to the difference in activation energies between the competitive reaction pathways.

Domaines

Chimie organique

Dates et versions

hal-00844052 , version 1 (12-07-2013)

Identifiants

Citer

René Grée, Danielle Gree. Effect of fluorine or oxygen atom(s) in propargylic position on the reactivity in click chemistry. Tetrahedron Letters, 2010, 51 (17), pp.2218-2221. ⟨10.1016/j.tetlet.2010.02.083⟩. ⟨hal-00844052⟩
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