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Article Dans Une Revue Tetrahedron Année : 2011

Setbacks and Hopes: En Route to the Synthesis of Uncialamycin

Sandy Desrat
Mickaël Jean

Résumé

We herein report a new approach toward the synthesis of uncialamycin, an enediyne natural product isolated from the Streptomyces uncialis, bacteria present on the surface of the lichen Cladonia uncialis. A model for the preparation of uncialamycin has been achieved through a reaction cascade, an acetylide addition to the activated quinoline moiety, and a ring closure reaction as key steps.

Domaines

Chimie organique

Dates et versions

hal-00843821 , version 1 (12-07-2013)

Identifiants

Citer

Sandy Desrat, Mickaël Jean, Pierre van de Weghe. Setbacks and Hopes: En Route to the Synthesis of Uncialamycin. Tetrahedron, 2011, 67 (39), pp.7510-7516. ⟨10.1016/j.tet.2011.07.090⟩. ⟨hal-00843821⟩
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