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Article Dans Une Revue Tetrahedron Letters Année : 2011

Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies

Résumé

We report a gold-catalyzed intramolecular hydroarylation of unactivated olefins using a combination of AuCl3/AgOTf as the catalytic system affording dihydrobenzopyrans, tetralins and tetrahydroquinolines in good yields. For our preliminary mechanistic studies, we have investigated the kinetic isotope effects with deuterated arene compounds and found that this catalytic hydroarylation is consistent with an electrophilic aromatic substitution process.

Domaines

Chimie organique

Dates et versions

hal-00843552 , version 1 (11-07-2013)

Identifiants

Citer

Mickael Jean, Pierre van de Weghe. Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies. Tetrahedron Letters, 2011, 52 (27), pp.3509-3513. ⟨10.1016/j.tetlet.2011.04.122⟩. ⟨hal-00843552⟩
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