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            <title xml:lang="en">Phosphine-free palladium-catalysed direct C2-arylation of benzothiophenes with aryl bromides</title>
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                <forename type="first">Liqin</forename>
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            <funder>We are grateful to the 'Chinese Scholarship Council' for a grant to L.Z. We thank the CNRS, 'Région Bretagne' and 'Rennes Métropole' for providing financial support.</funder>
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              <p>Ligand-free Pd(OAc)2 was found to catalyse very efficiently the direct C2-arylation of benzothiophene derivatives under low catalyst concentration. The reaction can be performed employing as little as 0.5-0.1 mol % catalyst with electron-deficient and some electron-rich aryl bromides. The presence of a methyl or a formyl substituent at C3 of benzothiophene has a minor influence on the reactivity, and even a bromo substituents at C3 is tolerated. A wide variety of functional groups on the aryl bromide, such as nitrile, nitro, acetyl, formyl, ester, chloro, fluoro or trifluoromethyl has been employed.</p>
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