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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2012

A concise and diastereoselective synthesis of piperidine and indolizidine alkaloids via aza-Prins cyclization

Basi V. Subba Reddy
  • Fonction : Auteur
Dudhmal N. Chaya
  • Fonction : Auteur
Jhillu S. Yadav
  • Fonction : Auteur
René Grée
  • Fonction : Auteur
  • PersonId : 940876

Résumé

The synthesis of 2-substituted and 2,4-disubstituted piperidine alkaloids such as (±)-coniine, (±)-hydroxypipecolic acid, (±)-pipecolic acid, (±)-coniceine, and (±)-4-hydroxy-2-hydroxymethyl piperidine have been accomplished in a highly diastereoselective manner by employing aza-Prins cyclization as a key step to construct the piperidine core of these alkaloids.
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Dates et versions

hal-00841538 , version 1 (05-07-2013)

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Citer

Basi V. Subba Reddy, Dudhmal N. Chaya, Jhillu S. Yadav, René Grée. A concise and diastereoselective synthesis of piperidine and indolizidine alkaloids via aza-Prins cyclization. Synthesis: Journal of Synthetic Organic Chemistry, 2012, 2012 (2), pp.297-303. ⟨10.1055/s-0031-1289648⟩. ⟨hal-00841538⟩
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