A concise and diastereoselective synthesis of piperidine and indolizidine alkaloids via aza-Prins cyclization
Résumé
The synthesis of 2-substituted and 2,4-disubstituted piperidine alkaloids such as (±)-coniine, (±)-hydroxypipecolic acid, (±)-pipecolic acid, (±)-coniceine, and (±)-4-hydroxy-2-hydroxymethyl piperidine have been accomplished in a highly diastereoselective manner by employing aza-Prins cyclization as a key step to construct the piperidine core of these alkaloids.