Towards chemical libraries based on heterocyclic scaffolds with monofluorinated and difluoroalkyl side chains - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Fluorine Chemistry Année : 2012

Towards chemical libraries based on heterocyclic scaffolds with monofluorinated and difluoroalkyl side chains

Résumé

The preparation of focused chemical libraries, based on five- and six-membered heteroaromatic systems with mono- and gemdifluoroalkyl side chains, is described. Four heterocyclic scaffolds with a p-bromophenyl group have been easily prepared from readily available propargylic fluorides. Starting from these scaffolds, palladium-catalyzed reactions have been performed, including by automated procedures, to prepare libraries of molecules designed for biological applications.

Dates et versions

hal-00841354 , version 1 (04-07-2013)

Identifiants

Citer

Pierre Bannwarth, Danielle Gree, René Grée, Saibal Das, Jhillu Singh Yadav. Towards chemical libraries based on heterocyclic scaffolds with monofluorinated and difluoroalkyl side chains. Journal of Fluorine Chemistry, 2012, 134 (Special issue), pp.180-187. ⟨10.1016/j.jfluchem.2011.03.003⟩. ⟨hal-00841354⟩
53 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More