Repair of bone defect using bioglass-chitosan as a pharmaceutical drug: An experimental study in an ovariectomised rat model - Université de Rennes Accéder directement au contenu
Article Dans Une Revue African Journal of Pharmacy and Pharmacology Année : 2012

Repair of bone defect using bioglass-chitosan as a pharmaceutical drug: An experimental study in an ovariectomised rat model

Bui Xv
  • Fonction : Auteur
Hassib Keskes
  • Fonction : Auteur
Tarek Rebai
  • Fonction : Auteur
Abdelfattah El Feki
  • Fonction : Auteur
Hafed El Feki
  • Fonction : Auteur

Résumé

Bone loss associated with skeletal trauma or metabolic diseases often require bone grafting. The present study aimed to evaluate the performance of bioactive glass-chitosan composite (BG-CH) produced by a freeze-drying process. BG containing 17% wt% CH was implanted in the femoral condyl of an ovariectomised rat. The resected bone was prepared for analysis using several physico-chemical techniques such as fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray (EDX). After 2 weeks, the implanted sample gave a spectrum in which two pronounced absorption bands with the maxima at 932 and 1036 cm(-1) arising from (Si-O-Si) groups disappeared 15 days after surgery. These bands were replaced 30 days after implantation by 601 and 564 cm(-1) (P- O) arisen form bone apatite bands. After 4 weeks, peaks at 31.6 and 25.8 degrees (2 theta) were registered thus inducing a degradation of BG-CH which occurred simultaneously with the implant replacement by the bone cells. Our data showed that the incorporation of 17% wt% CH with BG matrix promoted a highly significant bioactivity and generated an osteoinductive property. These effects might make BG-CH an effective biomaterials choice for the biomedical field.
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Dates et versions

hal-00816936 , version 1 (23-04-2013)

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Citer

Samira Jebahi, Hassane Oudadesse, Bui Xv, Hassib Keskes, Tarek Rebai, et al.. Repair of bone defect using bioglass-chitosan as a pharmaceutical drug: An experimental study in an ovariectomised rat model. African Journal of Pharmacy and Pharmacology, 2012, 6 (16), pp.1276-1287. ⟨10.5897/ajpp12.214⟩. ⟨hal-00816936⟩
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