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Article Dans Une Revue ACS Comb Sci Année : 2012

Synthesis of azaphilone-based chemical libraries.

Résumé

The synthesis of azaphilone scaffolds that have been further diversified by cross coupling acylation and amine addition is reported. Methodology development also led to novel modifications including C5 acetoxylation and condensations producing isoquinolin-6(7H) structures. Overall, the library synthesis afforded three azaphilone sublibraries, including vinylogous pyridones which project diversity elements in four sectors of the azaphilone core.

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Catalyse

Dates et versions

hal-00804933 , version 1 (26-03-2013)

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Citer

Mathieu Achard, Aaron B Beeler, John A Porco. Synthesis of azaphilone-based chemical libraries.. ACS Comb Sci, 2012, 14 (3), pp.236-44. ⟨10.1021/co300002x⟩. ⟨hal-00804933⟩
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