New 4-deoxy-(1→3)-β-D-glucan-based oligosaccharides and their immunostimulating potential. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Carbohydrate Research Année : 2011

New 4-deoxy-(1→3)-β-D-glucan-based oligosaccharides and their immunostimulating potential.

Vaclav Vetvicka
  • Fonction : Auteur
Sujata Saraswat-Ohri
  • Fonction : Auteur
Aruna Vashishta
  • Fonction : Auteur
Frank Jamois
  • Fonction : Auteur
Jean-Claude Yvin
  • Fonction : Auteur

Résumé

(1→3)-β-D-Glucans are well-established natural biological immunomodulators. However, problems inherited with the natural origin of these polysaccharides bring about significant setbacks, including batch-to-batch heterogeneity and significant differences based on the source and isolation techniques. In this study, we tried to overcome these problems by preparation of a quantitatively new set of oligo-(1→3)-β-D-glucan-based synthetic immunomodulators. Some of these non-natural oligosaccharides showed biological activities, such as stimulation of phagocytosis, modulation of gene expression, and anti-cancer activity, which were superior to natural glucans.

Domaines

Chimie organique

Dates et versions

hal-00753333 , version 1 (19-11-2012)

Identifiants

Citer

Vaclav Vetvicka, Sujata Saraswat-Ohri, Aruna Vashishta, Karine Descroix, Frank Jamois, et al.. New 4-deoxy-(1→3)-β-D-glucan-based oligosaccharides and their immunostimulating potential.. Carbohydrate Research, 2011, 346 (14), pp.2213-21. ⟨10.1016/j.carres.2011.06.020⟩. ⟨hal-00753333⟩
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