Automation of labelling of Lipiodol with high-activity generator-produced 188Re. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Applied Radiation and Isotopes Année : 2011

Automation of labelling of Lipiodol with high-activity generator-produced 188Re.

Résumé

This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol ((188)Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).

Domaines

Chimie organique

Dates et versions

hal-00752790 , version 1 (16-11-2012)

Identifiants

Citer

Nicolas Lepareur, Valérie Ardisson, Nicolas Noiret, Eveline Boucher, Jean-Luc Raoul, et al.. Automation of labelling of Lipiodol with high-activity generator-produced 188Re.. Applied Radiation and Isotopes, 2011, 69 (2), pp.426-30. ⟨10.1016/j.apradiso.2010.11.001⟩. ⟨hal-00752790⟩
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