Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Blood Année : 2011

Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.

Ash A. Alizadeh
  • Fonction : Auteur
Andrew J. Gentles
  • Fonction : Auteur
Alvaro J. Alencar
  • Fonction : Auteur
Chih Long Liu
  • Fonction : Auteur
Holbrook E. Kohrt
  • Fonction : Auteur
Roch Houot
  • Fonction : Auteur
  • PersonId : 946363
Matthew J. Goldstein
  • Fonction : Auteur
Shuchun Zhao
  • Fonction : Auteur
Ranjana H. Advani
  • Fonction : Auteur
Randy D. Gascoyne
  • Fonction : Auteur
Javier Briones
  • Fonction : Auteur
Robert J. Tibshirani
  • Fonction : Auteur
June H. Myklebust
  • Fonction : Auteur
Sylvia K. Plevritis
  • Fonction : Auteur
Izidore S. Lossos
  • Fonction : Auteur
Ronald Levy
  • Fonction : Auteur

Résumé

Several gene-expression signatures predict survival in diffuse large B-cell lymphoma (DLBCL), but the lack of practical methods for genome-scale analysis has limited translation to clinical practice. We built and validated a simple model using one gene expressed by tumor cells and another expressed by host immune cells, assessing added prognostic value to the clinical International Prognostic Index (IPI). LIM domain only 2 (LMO2) was validated as an independent predictor of survival and the "germinal center B cell-like" subtype. Expression of tumor necrosis factor receptor superfamily member 9 (TNFRSF9) from the DLBCL microenvironment was the best gene in bivariate combination with LMO2. Study of TNFRSF9 tissue expression in 95 patients with DLBCL showed expression limited to infiltrating T cells. A model integrating these 2 genes was independent of "cell-of-origin" classification, "stromal signatures," IPI, and added to the predictive power of the IPI. A composite score integrating these genes with IPI performed well in 3 independent cohorts of 545 DLBCL patients, as well as in a simple assay of routine formalin-fixed specimens from a new validation cohort of 147 patients with DLBCL. We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL.

Domaines

Cancer

Dates et versions

hal-00743991 , version 1 (22-10-2012)

Identifiants

Citer

Ash A. Alizadeh, Andrew J. Gentles, Alvaro J. Alencar, Chih Long Liu, Holbrook E. Kohrt, et al.. Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.. Blood, 2011, 118 (5), pp.1350-8. ⟨10.1182/blood-2011-03-345272⟩. ⟨hal-00743991⟩
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