Role of matrix metalloproteinases in the inflammatory process of respiratory diseases. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Molecular and Cellular Cardiology Année : 2010

Role of matrix metalloproteinases in the inflammatory process of respiratory diseases.

Résumé

Matrix metalloproteinases (MMPs) are a group of proteases known to regulate the turnover of extracellular matrix and thus are suggested to be important in the process of several diseases associated with tissue remodeling. Furthermore, the concept that modulation of airway remodeling including excessive proteolysis damage of the tissue, may be of interest as a basis for future treatment. Degradation of extracellular matrix is currently associated with structural and recruited cell activation and release of inflammatory mediators and MMPs. Indeed, a marked increase in their expression is observed associated with a variety of inflammatory diseases, including respiratory pathologies. In these conditions, we have to consider MMPs as therapeutic targets which can be inhibited by non-selective and/or selective inhibitors as anti-inflammatory compounds. The present review aims to discuss the potential interest of the inhibition of MMP in inflammatory diseases with a focus on respiratory diseases.

Dates et versions

hal-00742216 , version 1 (16-10-2012)

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Citer

Vincent Lagente, Elisabeth Boichot. Role of matrix metalloproteinases in the inflammatory process of respiratory diseases.. Journal of Molecular and Cellular Cardiology, 2010, 48 (3), pp.440-4. ⟨10.1016/j.yjmcc.2009.09.017⟩. ⟨hal-00742216⟩
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