Tomographie par émission de positons au (18 F)-fluorodésoxyglucose dans les cancers du col utérin: évaluation ganglionnaire et valeur pronostique/prédictive des données de la tumeur primitive [((18)F)-fluorodeoxyglucose PET/CT in cervix cancer: lymph node assessment and prognostic/predictive value of primary tumour analysis]. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Cancer/Radiothérapie Année : 2011

Tomographie par émission de positons au (18 F)-fluorodésoxyglucose dans les cancers du col utérin: évaluation ganglionnaire et valeur pronostique/prédictive des données de la tumeur primitive [((18)F)-fluorodeoxyglucose PET/CT in cervix cancer: lymph node assessment and prognostic/predictive value of primary tumour analysis].

Résumé

PURPOSE: In cervix carcinoma: (a) to evaluate the ability of ((18)F)-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the lymph node detection; (b) to investigate the prognostic and predictive value of the primary cervical PET parameters. PATIENTS AND METHODS: Ninety patients treated for cervix carcinoma and evaluated initially by MRI and FGD PET were included. The performances of FDG-PET for lymph node detection (relatively to the lymph node dissection) have been described (sensitivity, specificity, positive predictive value and negative predictive value). PET tumour parameters analyzed were: maximum standard uptake value (SUVmax), the volume and the maximum diameter. The prognostic and predictive values of these parameters were investigated. The tumour response was evaluated on surgical specimens. RESULTS: PET detected the cervical tumour with a sensitivity of 97% (mean values: SUVmax=15.8, volume=27 mm(3), maximum diameter=47). For the detection of the lymph nodes, the values of sensibility, specificity, positive predictive value and negative predictive value were: 86, 56, 69 and 78% in the pelvic, and 90, 67, 50 and 95% for the para-aortic area, respectively. The SUVmax was correlated with histologic response (P=0.04). The frequency of partial histological response was significantly higher for tumour SUVmax>10.9 (P=0.017). The maximum PET diameter and pathologic response had an impact on disease-free survival and overall survival in multivariate analysis (P<0.05). CONCLUSION: PET has high sensitivity in detecting pelvic and para-aortic lymph nodes. Some primary cervical tumour PET parameters are useful as prognostic and predictive factors.

Domaines

Cancer

Dates et versions

hal-00739967 , version 1 (09-10-2012)

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Citer

Julie Leseur, Anne Devillers, Danièle Williaume, Elisabeth Le Prisé, C. Fougerou, et al.. Tomographie par émission de positons au (18 F)-fluorodésoxyglucose dans les cancers du col utérin: évaluation ganglionnaire et valeur pronostique/prédictive des données de la tumeur primitive [((18)F)-fluorodeoxyglucose PET/CT in cervix cancer: lymph node assessment and prognostic/predictive value of primary tumour analysis].. Cancer/Radiothérapie, 2011, 15 (8), pp.699-708. ⟨10.1016/j.canrad.2011.05.013⟩. ⟨hal-00739967⟩
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