Spontaneous megakaryocytic colony formation does not discriminate between essential thrombocythemia and polycythemia vera. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue American Journal of Hematology Année : 2006

Spontaneous megakaryocytic colony formation does not discriminate between essential thrombocythemia and polycythemia vera.

Résumé

Laboratory detection of spontaneous growth of colony-forming unit-megacaryocytes (CFU-MK), allowing us to distinguish essential thrombocythemia (ET) from reactive thrombocytosis, is therefore useful for the diagnostic of this myeloproliferative disorder. Whether CFU-MK assays allow us to discriminate at least partly between ET and other myeloproliferative disorders such as polycythemia vera (PV) remains, however, to be established. To gain insights about this point, we have performed CFU-MK cultures from bone marrow cells of patients diagnosed with ET (n = 42) or PV (n = 50) using a standardized collagen-based serum-free method. Spontaneous growth of CFU-MK was similarly detected in both 40/42 patients with ET and 47/50 patients with PV. These data suggest clearly that the CFU-MK assay is useful to detect not only ET, but also PV, but fails to discriminate, even partly, between these two myeloproliferative disorders.

Dates et versions

hal-00699518 , version 1 (21-05-2012)

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Martine Escoffre-Barbe, Laurence Amiot, Pascale Beaucournu, Patrick Jego, Isabelle Grulois, et al.. Spontaneous megakaryocytic colony formation does not discriminate between essential thrombocythemia and polycythemia vera.. American Journal of Hematology, 2006, 81 (7), pp.554-6. ⟨10.1002/ajh.20592⟩. ⟨hal-00699518⟩
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