Glycosiderophores: Synthesis of tris-hydroxamate siderophores based on a galactose or glycero central scaffold, Fe(III) complexation studies. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Inorganic Biochemistry Année : 2012

Glycosiderophores: Synthesis of tris-hydroxamate siderophores based on a galactose or glycero central scaffold, Fe(III) complexation studies.

Résumé

A series of five new hexadentate tris-hydroxamate ligands based on a d-galactose or a glycerol scaffold have been synthesized. Protonation and ferric complex formation constants have been determined from solution studies by potentiometric and spectrophotometric titrations. All ligands form 1:1 Fe:L complexes. The calculated pFe values at pH 7.4 span over the range 19.2-23.0 depending on the scaffold and on the length of the spacers between hydroxamate and central scaffold and on the N-methyl substitution. This new kind of artificial siderophores based on a glycoscaffold is of interest as it opens up an easy way to modulate the pFe.

Domaines

Chimie organique

Dates et versions

hal-00694398 , version 1 (04-05-2012)

Identifiants

Citer

Christelle Neff, François Bellot, Jenny-Birgitta Waern, François Lambert, Jérémy Brandel, et al.. Glycosiderophores: Synthesis of tris-hydroxamate siderophores based on a galactose or glycero central scaffold, Fe(III) complexation studies.. Journal of Inorganic Biochemistry, 2012, 112C, pp.59-67. ⟨10.1016/j.jinorgbio.2012.02.030⟩. ⟨hal-00694398⟩
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