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Article Dans Une Revue Leukemia Research Année : 2008

Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases.

Résumé

We report on the clinico-biological characteristics of 20 cases of gammadelta T cell large granular lymphocyte (LGL) leukemia. All the data were compared to that of 196 cases with alphabeta T cell subtype, which represents the majority of T cell LGL leukemias. Clinical findings were quite similar in the two groups regarding age, sex ratio, recurrent infections, and association with auto-immune diseases especially rheumatoid arthritis. Gammadelta LGL predominantly expressed a CD3+/CD4-/CD8+/CD16+/CD57+ phenotype, in 50% of cases. Clinical outcome was favorable for these patients with overall survival of 85% at 3 years. Fifty percent of gammadelta patients required treatment and the response to therapy was estimated at 55%. gammadelta and alphabeta T cell LGL leukemia harbor a very similar clinico-biological behavior and represent part of an antigen-driven T cell lymphoproliferation.

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Dates et versions

hal-00690765 , version 1 (24-04-2012)

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Citer

A. S. Bourgault-Rouxel, T. P. Loughran, Renato Zambello, P. K. Epling-Burnette, G. Semenzato, et al.. Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases.. Leukemia Research, 2008, 32 (1), pp.45-8. ⟨10.1016/j.leukres.2007.04.011⟩. ⟨hal-00690765⟩
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