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Article Dans Une Revue Cellular and Molecular Life Sciences Année : 2011

Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?

Résumé

Although the expression of the non-classical HLA class I molecule HLA-G was first reported to be restricted to the fetal-maternal interface on the extravillous cytotrophoblasts, the distribution of HLA-G in normal tissues appears broader than originally described. HLA-G expression was found in embryonic tissues, in adult immune privileged organs, and in cells of the hematopoietic lineage. More interestingly, under pathophysiological conditions HLA-G antigens may be expressed on various types of malignant cells suggesting that HLA-G antigen expression is one strategy used by tumor cells to escape immune surveillance. In this article, we will focus on HLA-G expression in cancers of distinct histology and its association with the clinical course of diseases, on the underlying molecular mechanisms of impaired HLA-G expression, on the immune tolerant function of HLA-G in tumors, and on the use of membrane-bound and soluble HLA-G as a diagnostic or prognostic biomarker to identify tumors and to monitor disease stage, as well as on the use of HLA-G as a novel therapeutic target in cancer.

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Domaines

Cancer

Dates et versions

hal-00682022 , version 1 (23-03-2012)

Identifiants

Citer

Laurence Amiot, Soldano Ferrone, Hans Grosse-Wilde, Barbara Seliger. Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?. Cellular and Molecular Life Sciences, 2011, 68 (3), pp.417-31. ⟨10.1007/s00018-010-0583-4⟩. ⟨hal-00682022⟩
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