Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue European Journal of Immunology Année : 2008

Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells.

Résumé

HLA-G molecules are known to exert immunosuppressive action on DC maturation and on NK cells, and can in consequence inhibit respectively T cell responses and NK cytolysis. In this study, we show that monocyte-derived DC, differentiated in the presence of GM-CSF and IL-4, are sensitive to soluble (s) HLA-G molecules during LPS/IFN-gamma maturation as demonstrated by the decrease of CD80 and HLA-DR expressions and IL-12 secretion. Moreover, DC pretreated with sHLA-G were found to activate NK/DC crosstalk less than non-treated DC. Early activation of NK cells co-cultured with autologous DC was diminished as assessed by CD69 expression. The IFN-gamma production was impaired whereas a slight inhibition of the NK cell cytotoxicity against Daudi cell line was observed. Since sHLA-G is expressed in grafts or sites of tumour proliferation, its indirect action on NK cells via DC could constitute a pathway of early inhibition for both innate and specific immune responses.

Domaines

Immunologie
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Dates et versions

hal-00675944 , version 1 (02-03-2012)

Identifiants

Citer

Frédéric Gros, Florian Cabillic, Olivier Toutirais, Amélie Le Maux, Yasmine Sebti, et al.. Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells.. European Journal of Immunology, 2008, 38 (3), pp.742-9. ⟨10.1002/eji.200736918⟩. ⟨hal-00675944⟩
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