Palladium-catalysed direct arylations of heteroaromatics using more eco-compatible solvents pentan-1-ol or 3-methylbutan-1-ol - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Tetrahedron Letters Année : 2011

Palladium-catalysed direct arylations of heteroaromatics using more eco-compatible solvents pentan-1-ol or 3-methylbutan-1-ol

Résumé

The palladium-catalysed direct coupling of aryl halides with heteroaromatics in greener solvents than DMF or DMAc, which are often employed for such couplings, would be a considerable advantage for both industrial application and sustainable development. We observed that a range of aryl bromides undergoe coupling via C-H bond activation/functionalisation reaction of thiazoles or imidazoles in moderate to good yields using pentan-1-ol or 3-methylbutan-1-ol as the solvents. Pentan-1-ol and 3-methylbutan-1-ol are less toxic than DMF or DMAc, moreover they are bioresources as they can be obtained by fermentation. Therefore, these reaction conditions are certainly more eco-compatible than those generally employed for such couplings.

Domaines

Catalyse

Dates et versions

hal-00632071 , version 1 (13-10-2011)

Identifiants

Citer

Souhila Bensaid, Nouria Laidaoui, Douniazad El Abed, Soufi Kacimi, Henri Doucet. Palladium-catalysed direct arylations of heteroaromatics using more eco-compatible solvents pentan-1-ol or 3-methylbutan-1-ol. Tetrahedron Letters, 2011, 52 (12), pp.1383-1387. ⟨10.1002/chin.201126136⟩. ⟨hal-00632071⟩
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