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Article Dans Une Revue Tetrahedron Letters Année : 2010

Cyclen-Catalyzed Henry Reaction under Neutral Conditions

Résumé

A convenient cyclen-catalyzed Henry reaction of aldehydes with nitroalkanes under mild and neutral conditions is reported. This procedure constitutes the first cyclen-catalyzed synthesis of nitroalcohols and is adapted to the condensation of both aromatic and aliphatic aldehydes with nitromethane in THF at room temperature without addition of stoichiometric amount of the base. A wide range of substrates, β-nitroalcohols, were obtained in moderate to good yields (up to 98%) using this methodology.

Domaines

Catalyse

Dates et versions

hal-00576912 , version 1 (15-03-2011)

Identifiants

Citer

Chloé Vovard-Le Bray, Fan Jiang, Xiao-Feng Wu, Jean-Baptiste Sortais, Christophe Darcel. Cyclen-Catalyzed Henry Reaction under Neutral Conditions. Tetrahedron Letters, 2010, 51 (34), pp.4555-4557. ⟨10.1016/j.tetlet.2010.06.106⟩. ⟨hal-00576912⟩
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