Defining specificity of transcription factor regulatory activities. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Cell Science Année : 2009

Defining specificity of transcription factor regulatory activities.

Résumé

Mammalian transcription factors (TFs) are often involved in differential cell-type- and context-specific transcriptional responses. Recent large-scale comparative studies of TF recruitment to the genome, and of chromatin structure and gene expression, have allowed a better understanding of the general rules that underlie the differential activities of a given TF. It has emerged that chromatin structure dictates the differential binding of a given TF to cell-type-specific cis-regulatory elements. The subsequent regulation of TF activity then ensures the functional activation of only the precise subset of all regulatory sites bound by the TF that are required to mediate appropriate gene expression. Ultimately, the organization of the genome within the nucleus, and crosstalk between different cis-regulatory regions involved in gene regulation, also participate in establishing a specific transcriptional program. In this Commentary, we discuss how the integration of these different and probably intimately linked regulatory mechanisms allow for TF cell-type- and context-specific modulation of gene expression.
Fichier non déposé

Dates et versions

hal-00436576 , version 1 (27-11-2009)

Identifiants

Citer

Jérôme Eeckhoute, Raphaël Métivier, Gilles Salbert. Defining specificity of transcription factor regulatory activities.. Journal of Cell Science, 2009, 122 (Pt 22), pp.4027-34. ⟨10.1242/jcs.054916⟩. ⟨hal-00436576⟩
46 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More