Absence of direct effect of low-power millimeter-wave radiation at 60.4 GHz on endoplasmic reticulum stress - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Cell Biology and Toxicology Année : 2009

Absence of direct effect of low-power millimeter-wave radiation at 60.4 GHz on endoplasmic reticulum stress

Résumé

Millimeter waves (MMW) at frequencies around 60 GHz will be used in the very near future in the emerging local wireless communication systems and the potential health hazards of artificially induced environmental exposures represent a major public concern. The main aim of this study was to investigate the potential effects of low-power MMW radiations on cellular physiology. To this end, the human glial cell line, U-251 MG, was exposed to 60.4 GHz radiation at a power density of 0.14 mW/cm2 and potential effect of MMW radiations on endoplasmic reticulum (ER) stress was investigated. ER is very sensitive to environmental insults and its homeostasis is altered in various pathologies. Through several assay systems, we found that exposure to 60.4 GHz does not modify ER protein folding and secretion, nor induces XBP1 or ATF6 transcription factors maturation. Moreover, expression of ER-stress sensor, BiP/GRP78 was examined by real-time PCR, in exposed or non-exposed cells to MMW radiations. Our data demonstrated the absence of significant changes in mRNA levels for BiP/GRP78. Our results showed that ER homeostasis does not undergo any modification at molecular level after exposure to low-power MMW radiation at 60.4 GHz. This report is the first study of ER-stress induction by MMW radiations.

Dates et versions

hal-00406594 , version 1 (23-07-2009)

Identifiants

Citer

Christophe Nicolas Nicolaz, Maxim Zhadobov, Fabienne Desmots, Ronan Sauleau, Daniel Thouroude, et al.. Absence of direct effect of low-power millimeter-wave radiation at 60.4 GHz on endoplasmic reticulum stress. Cell Biology and Toxicology, 2009, 25 (5), pp.471-478. ⟨10.1007/s10565-008-9101-y⟩. ⟨hal-00406594⟩
145 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More