Holoprosencephaly-Polydactyly syndrome: in search of an etiology. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue European Journal of Medical Genetics Année : 2008

Holoprosencephaly-Polydactyly syndrome: in search of an etiology.

Résumé

Holoprosencephaly-Polydactyly (HPS) or Pseudotrisomy 13 syndrome are names conferred to clinically categorize patients whose phenotype is congruent with Trisomy 13 in the context of a normal karyotype. The literature suggests that this entity may be secondary to submicroscopic deletions in holoprosencephaly (HPE) genes; however, a limited number of investigations have been undertaken to evaluate this hypothesis. To test this hypothesis we studied a patient with HPE, polydactyly, and craniofacial dysmorphologies consistent with the diagnosis of Trisomy 13 whose karyotype was normal. We performed mutational analysis in the four main HPE causing genes (SHH, SIX3, TGIF, and ZIC2) and GLI3, a gene associated with polydactyly as well as fluorescent in situ hybridization (FISH) to search for microdeletions in these genes and two candidate HPE genes (DISP1 and FOXA2). No mutations or deletions were detected. A whole genome approach utilizing array Comparative Genomic Hybridization (aCGH) to screen for copy number abnormalities was then taken. No loss or gain of DNA was noted. Although a single case, our results suggest that coding mutations in these HPE genes and copy number anomalies may not be causative in this disorder. Instead, HPS likely involves mutations in other genes integral in embryonic development of the forebrain, face and limbs. Our systematic analysis sets the framework to study other affected children and delineate the molecular etiology of this disorder.

Dates et versions

hal-00203732 , version 1 (11-01-2008)

Identifiants

Citer

Dwight R Cordero, Claude Bendavid, Alan L Shanske, Bassem R Haddad, Maximilian Muenke. Holoprosencephaly-Polydactyly syndrome: in search of an etiology.. European Journal of Medical Genetics, 2008, 51 (2), pp.106-12. ⟨10.1016/j.ejmg.2007.08.004⟩. ⟨hal-00203732⟩
50 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More