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Chapitre D'ouvrage Année : 2005

Regulation and function of estrogen receptors: Comparative aspects

Résumé

In vertebrates, E2 is largely involved in many physiological mechanisms starting in embryonic development and continuing throughout adult stages. In fish, its effects are best documented in the context of the hormonal regulations along the brain-pituitary-gonads axis. Moreover, in oviparous species including fish, E2 also controls the vitellogenesis process at level of the liver. Genomic E2 effects are mediated by estrogen receptors, namely ERα and ERβ, acting as ligand-dependent transcription factors. Although, the teleost ERs share similar characteristics with mammalian ERs, studies on fish ERs have recently provided valuable and novel data on the ER functions. First, in addition to the full length ERα, an N-terminal truncated ERα isoform was identified in teleost species. This novel isoform is mainly, if not exclusively, expressed in the liver and is characterized by a constitutive ligand-independent activity. This short ERΑ isoform, which is also found in other oviparous species may be relevant to the hepatic vitellogenesis process. Second, most fish are also characterized by the presence of two distinct forms of ERβ, ERβ1 and ERβ2, issued from a gene duplication early in the fish lineage duplication. The analysis of their transcriptional activities and their tissue distributions in zebrafish showed that these ERβ forms are functional and probably exert differential functions, as indicated by their different patterns of expression. This review focuses on the most recent developments regarding the original characteristics of fish ER and their involvement in the regulation of E2-dependent genes. In addition to the importance of this new information with respect to the molecular mechanisms underlying the physiological effects of E2, this research also provides stronger bases to evaluate the impact of estrogenic environmental contaminants on the animal development and physiology
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Dates et versions

hal-00022135 , version 1 (03-04-2006)

Identifiants

  • HAL Id : hal-00022135 , version 1

Citer

Arnaud Menuet, Fátima Adrio, Olivier Kah, Farzad Pakdel. Regulation and function of estrogen receptors: Comparative aspects. Philippa Melamed Nancy Sherwood. HORMONES AND THEIR RECEPTORS IN FISH REPRODUCTION, World Scientific, pp.224-253, 2005, Molecular Aspects of Fish and Marine Biology - Vol. 4. ⟨hal-00022135⟩
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