Properties and development of calcium currents in embryonic cockroach neurons. - UFR SVE Sciences de la vie et de l'environnement Accéder directement au contenu
Article Dans Une Revue Neuroscience Letters Année : 2000

Properties and development of calcium currents in embryonic cockroach neurons.

P. Benquet
  • Fonction : Auteur
S. Frere
  • Fonction : Auteur
F. Tiaho
  • Fonction : Auteur

Résumé

In freshly dissociated neurons from embryonic cockroach (Periplaneta americana L.) brains, voltage-dependent calcium currents appear early in development (E14). Their intensity increases progressively during embryonic life until eclosion (E35). Their time course and voltage dependency are characteristic of high voltage activated (HVA) currents although a 10 mV shift of the I/V curve towards more negative potentials was observed between E18 and E23. Their sensitivity to omega-AgaTx-IVA and omega-CgTx-GVIA and insensitivity to both amiloride and isradipine indicate that the corresponding channels are of the P/Q and N types. These channels, as well as a small proportion of toxin-resistant (R) channels (about 20%), are blocked by mibefradil and verapamil. The physiological significance of these currents and their modifications during embryonic life is discussed.

Domaines

Neurosciences

Dates et versions

hal-00982289 , version 1 (23-04-2014)

Identifiants

Citer

P. Benquet, S. Frere, Y. Pichon, F. Tiaho. Properties and development of calcium currents in embryonic cockroach neurons.. Neuroscience Letters, 2000, 294 (1), pp.49-52. ⟨10.1016/S0304-3940(00)01549-4⟩. ⟨hal-00982289⟩
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