Impact of intraventricular septal fiber orientation on cardiac electromechanical function - Biology of Cardiovascular Diseases Accéder directement au contenu
Article Dans Une Revue AJP - Heart and Circulatory Physiology Année : 2022

Impact of intraventricular septal fiber orientation on cardiac electromechanical function

Jairo Rodríguez-Padilla
Argyrios Petras
Julie Magat
Jason Bayer
Yann Bihan-Poudec
Dounia El Hamrani
  • Fonction : Auteur
Aurel Neic
  • Fonction : Auteur
Christoph M Augustin
  • Fonction : Auteur
Fanny Vaillant
  • Fonction : Auteur
Marion Constantin
  • Fonction : Auteur
Line Pourtau
  • Fonction : Auteur
Virginie Dubes
  • Fonction : Auteur
Julien Rogier
  • Fonction : Auteur
Michel Haïssaguerre
  • Fonction : Auteur
Matthias Gsell
  • Fonction : Auteur
Gernot Plank
  • Fonction : Auteur
Edward Vigmond
  • Fonction : Auteur

Résumé

Cardiac fiber direction is an important factor determining the propagation of electrical activity, as well as the development of mechanical force. In this article, we imaged the ventricles of several species with special attention to the intraventricular septum to determine the functional consequences of septal fiber organization. First, we identified a dual-layer organization of the fiber orientation in the intraventricular septum of ex vivo sheep hearts using diffusion tensor imaging at high field MRI. To expand the scope of the results, we investigated the presence of a similar fiber organization in five mammalian species (rat, canine, pig, sheep, and human) and highlighted the continuity of the layer with the moderator band in large mammalian species. We implemented the measured septal fiber fields in three-dimensional electromechanical computer models to assess the impact of the fiber orientation. The downward fibers produced a diamond activation pattern superficially in the right ventricle. Electromechanically, there was very little change in pressure volume loops although the stress distribution was altered. In conclusion, we clarified that the right ventricular septum has a downwardly directed superficial layer in larger mammalian species, which can have modest effects on stress distribution. NEW & NOTEWORTHY A dual-layer organization of the fiber orientation in the intraventricular septum was identified in ex vivo hearts of large mammals. The RV septum has a downwardly directed superficial layer that is continuous with the moderator band. Electrically, it produced a diamond activation pattern. Electromechanically, little change in pressure volume loops were noticed but stress distribution was altered. Fiber distribution derived from diffusion tensor imaging should be considered for an accurate strain and stress analysis.
Fichier principal
Vignette du fichier
Rodriguez padilla et al-Am J Physiol heart Circ Physiol .2022.pdf (9.9 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03869234 , version 1 (24-11-2022)

Identifiants

Citer

Jairo Rodríguez-Padilla, Argyrios Petras, Julie Magat, Jason Bayer, Yann Bihan-Poudec, et al.. Impact of intraventricular septal fiber orientation on cardiac electromechanical function. AJP - Heart and Circulatory Physiology, 2022, 322 (6), pp.H936 - H952. ⟨10.1152/ajpheart.00050.2022⟩. ⟨hal-03869234⟩
49 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More