Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia - Biology of Cardiovascular Diseases Accéder directement au contenu
Article Dans Une Revue British Journal of Haematology Année : 2015

Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia

Résumé

Persistent or chronic immune thrombocytopenias (P/C-ITP) are acquired blood disorders lasting more than 3 months or 1 year, respectively. The pathogenesis of these disorders is thought to be immunological. We hypothesized that some patients with P/C-ITP might have an intrinsic megakaryopoiesis defect. We identified a group of P/C-ITP patients with acquired isolated mild thrombocytopenia (30-100 × 10(9) /l), undetectable anti-platelet antibodies, negative autoimmune investigations and no need for treatment. We examined in vitro megakaryocyte differentiation and compared these patients' results with those of acute-ITP patients and healthy controls. No difference in proliferation, ploidy or expression of surface markers was found. In contrast, P/C-ITP patients had significantly fewer proplatelet-forming megakaryocytes. This novel observation demonstrated that some patients diagnosed with P/C-ITP have an intrinsic megakaryopoiesis defect independent of the bone-marrow environment. Further investigations are needed to dissect mechanisms underlying this impaired proplatelet formation in these patients.

Mots clés

Dates et versions

hal-02980037 , version 1 (27-10-2020)

Identifiants

Citer

Étienne Rivière, Jean-François Viallard, Alexandre Guy, Badr Kilani, Juliana Vieira-Dias, et al.. Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia. British Journal of Haematology, inPress, 170 (3), pp.408-415. ⟨10.1111/bjh.13444⟩. ⟨hal-02980037⟩

Collections

CNRS U1034
10 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More