Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2025

4-hydroxypiperidines containing a quaternary stereocenter by aza-Prins cyclization

Résumé

A straightforward and highly diastereoselective synthesis of cis-4-hydroxypiperidines is presented. This method allows access to C2 and C4 substituted piperidines, bearing a tetrasubstituted carbon stereocenter at C4. gem-Disubstituted homoallylic amines and ketoaldehydes as carbonyl partners have been rarely used in aza-Prins cyclizations, expanding the scope of this reaction.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
draft full.pdf (859.58 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04919312 , version 1 (29-01-2025)

Identifiants

Citer

Myriam Le Roch, Nicolas Gouault, Jacques Renault, Gilles Argouarch, Thierry Roisnel, et al.. 4-hydroxypiperidines containing a quaternary stereocenter by aza-Prins cyclization. Organic & Biomolecular Chemistry, In press, ⟨10.1039/d4ob01807a⟩. ⟨hal-04919312⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More